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These medications work through entirely different mechanismsliraglutide acts on GLP-1 receptors primarily in the gastrointestinal system and brain appetite centres, whilst sertraline modulates serotonin reuptake in the central nervous system
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10.1158/1055-9965.EPI-16-0968 173 ZhaoJ.MiaoK.WangH.DingH.WangD
(2) Gastrointestinal GPx (GPx2) is only found in the cytosol and nucleus of the gastrointestinal tract
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![Can Semaglutide Bind Tighter to GLP-1R?[v1]](https://www.preprints.org/frontend/manuscript/482d59f0f300944b525be5295c72aeca/download_pub/figure/preprints-30101-grafic.png)
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