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only the precursor 5-HTP passes the blood-brain barrier
doi: 10.1152/ajpendo.00471.2015 93 LundAVilsbllTBaggerJIHolstJJKnopFK
In an associated Commentary titled Thyroid Cancer Risk with GLP-1 Receptor Agonists: Evidence, Knowledge Gaps, and the Path Forward, Juan Brito, MD , from the Mayo Clinic, and coauthors, stated the following: this study stands out for its large scale and robust methodology
However it should be noted that the overall and off-label use of GLP-1R agonists in 2023 are likely underestimated in the published study, as it doesnt include the recently approved member of this group, tirzepatide (Mounjaro), which induces even greater weight loss than Ozempic
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