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Figure 3 The PI3K/Akt signaling pathway is an intracellular signaling pathway that promotes metabolism, proliferation, cell survival, growth, and angiogenesis by responding to extracellular signals ( in vitro ( The Notch signaling pathway is a crucial intercellular interaction pathway comprising Notch ligands, Notch receptors, and intracellular effector molecules, and is closely associated with organ fibrosis ( in vitro and in mouse PVR models