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Environ Res
Glutathione plays a variety of roles in the body, including: regenerating other antioxidants (e.g., vitamin C, vitamin E) neutralizing free radicals detoxification of certain drugs regulating the immune system managing inflammation supporting various bodily systems (e.g., nervous system, pulmonary system) delaying cell aging Glutathione depletion is also linked to numerous health issues, including increased susceptibility to infectious diseases and illnesses, oxidative stress, and certain chronic diseases, such as type 2 diabetes, certain types of cancer, kidney disease, neurodegenerative disease, liver disease, and cardiovascular disease ( 1 , 2 )
Our previous study demonstrated that a 14-day daily administration of lenvatinib to rats reduced OCTN2 protein levels in the skeletal muscle and intestine, but not in the kidney, and consequently decreased L-carnitine content in the skeletal muscle (Jing et al., 2022)
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