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A phase 3 trial is currently evaluating retatrutide directly against tirzepatide in adults with obesity
JAMA 323 , 15741581 (2020)
That being said, current research supports evaluating the following nutrients at a minimum: 1
It occupies a scientifically legitimate space between those extremes: a peptide with a plausible endogenous origin, a well-characterized set of molecular targets, and an unusually consistent preclinical record across diverse injury models and species
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