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Nassirpour, R
For many GPCRs, homologous desensitization first requires the phosphorylation of the active state of the receptor by the G protein-coupled receptor kinase (GRK) family of kinases
Cardiovascular outcome trials have demonstrated significant reductions in major adverse cardiovascular events with certain agents in this class (liraglutide, injectable semaglutide, and dulaglutide), leading to expanded indications for cardiovascular risk reduction
Maintenance: Dose may be increased in increments of 2.5 mg every 4 weeks as needed
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