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Therefore, the SHAPE study (Real-World Weight Loss Observed With S emaglutide and Tirzepatide in Patients with Overweig H t or Obesity A nd Without Ty PE 2 Diabetes) aimed to evaluate the effectiveness of semaglutide 2.4 mg and tirzepatide in patients with overweight or obesity and without T2DM in routine clinical practice over a 1-year follow-up period
Therapeutic approaches that counterbalance this axis by improving resolution pathways, restoring immunological tolerance, and lowering peripheral inflammatory inputs are the most promising avenues for preventing or delaying neurodegeneration [137]
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