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Grading the strength of evidence The strength of evidence is very low limited mainly by the precision of estimates, risk of bias and potential publication bias of the included studies (Electronic Supplementary Table 3)
Once tirzepatide reaches therapeutic dose, many patients naturally consume 1,200-1,600 calories daily without hunger, allowing steady loss of 1-2 pounds per week without additional restriction
Semaglutide stimulates insulin secretion and controls blood sugar, which helps manage Type 2 diabetes
Additional findings Beyond weight loss, the Phase 2 trial revealed several additional benefits
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