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Major Criteria Skin hyperextensibility, with velvety skin texture and absence of atrophic scarring Generalized joint hypermobility, with or without recurrent dislocations (most commonly shoulder and ankle) Easily bruisable skin/spontaneous ecchymoses Minor Criteria Foot deformities (broad/plump forefoot

Enhance fibroblast migration and proliferation , essential for ligament, tendon, and skin repair

That is the evidence gap, stated plainly: the mechanism is well-motivated and the preclinical signal is consistent, but no human study has confirmed that any of it translates to people, at any dose, by any route

Adems, la actividad pro-angiognica motiva cautela terica en contextos de crecimiento tisular no deseado