There is no universal winner because both options work, just for different reasons and on different timelines
CrossRef Global research trends in bacteriophage and gut microbiota: a bibliometric and visual analysis from 2012 to 2025 Hui-Fang Kuang, Xiong-Yilang Jiang, Song-Yan Tie, Kun Lian, Mu-Yi Hao, Hang Xu, Xiao Huang, Yi Yang, Qian Guo, Jie Li, Ling-Li Chen Frontiers in Microbiology .2026;[Epub] CrossRef Cinobufagin as a Potential Intervention Against Liver CancerA Comprehensive Review Nicole Simone de Lima Coelho, Victria Dogani Rodrigues, Otvio Simes Girotto, Renato Csar Moretti Jnior, Vtor Engrcia Valenti, Maria Anglica Miglino, Mnica Duarte da Silva, Caio Srgio Galina Spilla, Ana Luiza Decanini Miranda de Souza, Sandra Mar Pharmaceuticals .2026
In studies, it acts on GHRH receptors in the anterior pituitary, stimulating endogenous release of growth hormone (GH) and increasing IGF-1 systemically and also locally in various tissues, with effects investigated in metabolism and body composition
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