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Thyroid dysfunction, insulin resistance, polycystic ovary syndrome, certain medications (like corticosteroids or some antidepressants), and hormonal imbalances can all impair weight loss response to semaglutide
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However, a number of RAS mutated cancer cells maintain their own growth and metabolism through high levels of autophagy, including those of colorectal cancer and pancreatic cancer (51)
doi:10.1016/j.foodchem.2014.08.035
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