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Human esophageal myofibroblasts secrete proinflammatory cytokines in response to acid and Toll-like receptor 4 ligands
Carnitine binds to these acyl CoA to form acyl carnitine and is excreted, while releasing free CoA to maintain sufficient free CoA in the body
The SPC expiration dates vary by country: Germany: June 2029 France: June 2029 United Kingdom (post-Brexit): June 2027 Spain: December 2028 Italy: December 2028 Formulation patents in the EU (EP 2 586 456) expire August 2031, two years earlier than the U.S
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