All of those require a known target
A WHO consultation identified the most vulnerable groups as elderly individuals, infants, preschool-aged children, and pregnant or lactating women, due to either increased nutritional demands or impaired absorption capacity ( Addressing the prevention of B12 deficiency and its public health implications requires a comprehensive, life-course approach based on integrated strategies targeting early detection, dietary optimisation, and effective supplementation, in order to mitigate the long-term consequences of inadequate cobalamin status ( Intramuscular (IM) injection is the most invasive and costly administration method, requiring trained personnel and clinical visits
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Twelve mice were randomly divided into 4 groups and injected into the tail vein with PBS, Ru(II)-OH, NP2, and NP4 (2 mg Ru/kg) on the days 1, 4, and 7