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Rare But Serious Digestive Side Effects of Semaglutide More serious side effects associated with semaglutide include the following: Pancreatitis, which is an inflammation of the pancreas that can cause swelling and pain Gallbladder disease, such as gallstones and gallbladder inflammation Intestinal obstruction, likely caused by slowing digestion, creating potential blockages of food and stool in the intestinal tract While concerning, these side effects are rare, according to Andy Lee, M.D., a cardiovascular disease specialist at UCI Health in California, who explains that these conditions are often associated with existing gallbladder or pancreatic disease, or competing medical issues like high triglycerides and alcohol intake. If a patient is at risk for gallstones or pancreatitis prior to starting semaglutide, I recommend caution, more frequent monitoring, and assessments to ensure tolerability, especially when the medication is being prescribed for obesity, continues Dr

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