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We demonstrated that in senescent vascular endothelial cells, FOXO4-DRI effectively disrupts the FOXO4-p53 interaction
Lo CH et al
When weight loss occurs gradually, the skin has more time to adapt and contract
11 GSH depletion and the subsequent low stores of protein thiol result in both calcium release from intracellular stores and inhibition of calcium extrusion, producing a marked increase in cytosolic calcium concentration, which triggers cytotoxicity
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