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Age-related decline in melatonin production is well documented in the literature: both peak nocturnal levels and circadian amplitude decrease progressively, reflecting functional changes in the pineal glands melatonin-producing capacity
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Wegovy and other GLP-1 receptor agonists have been associated with modest increases in resting heart rate (approximately 2-3 beats per minute on average according to the SmPC, though some individuals may experience larger increases)
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