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This in turn causes the thyroid to churn out an excess of thyroid hormones, leading to the hyperthyroidism of Graves disease

Patients with uncontrolled tachyarrhythmias, recent acute coronary syndrome, or unstable heart conditions should exercise caution and require thorough cardiovascular assessment before starting treatment

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That third target in retatrutide may account for the additional weight loss through increased energy expenditure, but it also raises a theoretical concern