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A preclinical safety study in Regulatory Toxicology and Pharmacology found BPC-157 well-tolerated with no severe toxic effects in mice, rats, rabbits, and dogs
It is suggested that this feedback loop between initial hyperactivation, hypophysitis/pituitary hypopituitarism and immune depletion may contribute to the development and persistence of LC and other infectious syndromes such as ME/CFS
In addition, treatment did not restore neurotrophin signaling and was associated with reductions in BDNF and NGF levels, suggesting a limited and potentially unfavorable impact on pathways involved in synaptic plasticity and neurodevelopment
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