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For men specifically, the data on male tirzepatide results shows that consistent dosing combined with resistance training and adequate protein intake produces the best body composition outcomes

Pain medications mask symptoms without addressing the underlying cause, and steroid injections provide only temporary relief

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A 2.6% reduction in hip bone mineral density and a 2.1% reduction at the lumbar spine in 52 weeks (Hansen et al., 2024), combined with up to 10.9% lean mass loss over 72 weeks (Look et al., 2025), means that patients on GLP-1 therapy need a comprehensive musculoskeletal protection plan from day one