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Unfortunately, MTX can trigger apoptosis in healthy tissues, including the liver (Abbas et al., 2023b)
Full details of comparison analyses are provided in Supplementary Information
Functionally, glutathione was essential for melatonin-mediated immunosuppression, as IKE co-treatment abolished the reductions in IL-5, IL-13, and IL-4 production observed with melatonin alone ( Figures 8FH )
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