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Experimental evidence indicated that while peptides bound to albumin do not penetrate the CNS, peripheral activation of the GLP-1R system would be coupled to neuronal activation and central effects of gastric emptying and decreased food intake, independent of direct exposure on the CNS [47]
Claims of multi-target actions are common, but without a clear understanding of the pharmacokinetics and tissue distribution of the key components, it is difficult to distinguish primary targets from secondary effects
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