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Each of these systems is compromised to varying degrees in T21 due to gene overexpression, oxidative stress, and immune dysregulation, making them ideal targets for metabolic restoration

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some authors proposed it for preterm babies affected by necrotizing enterocolitis 116 , for hemolytic hyperbilirubinemia-induced oxidative brain damage 117 , intrauterine fetal growth retardation 118,119,120,121 , chronic lung disease (CLD), and periventricular leukomalacia

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