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After opening, refrigerate it to maintain stability

Importantly, clinicians should discuss the possibility of transient gastrointestinal symptoms

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All DPP-4 inhibitors are orally active, specific for DPP-4 and with a high affinity to the enzyme, although their binding characteristics and pharmacokinetic properties differ ( Table 1 Structure, clinical dose (reflecting potency), and dates of approval by United States Food and Drug Administration (FDA) and European Medicines Agency (EMA) for the DPP-4 inhibitors, sitagliptin, vildagliptin, saxagliptin, alogliptin, and linagliptin, which were the first DPP-4 inhibitors reaching the market