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Enabling direct comparison of selective GLP-1R biology versus dual incretin receptor co-agonism to characterise the additive GIPR contributions to metabolic efficacy exceeding Semaglutides GLP-1R-only profile

It is primarily studied for its role in actin polymerisation, cell migration, and wound-healing cascades in laboratory models

It enrolled 2,339 adults with obesity or overweight (BMI 27) with at least one weight-related health condition, without type 2 diabetes

FDA-approved in 2014 for treating type 2 diabetes, its taken as a once-weekly injection that lowers blood sugar when combined with a healthy diet and regular exercise