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As a consequence, although clinical application of PAC may be considered as safe, in the case of severely depleted GSH levels PAC should be administered with caution, especially in subjects with severe GSH depletion who, again, are those at higher risk of developing severe COVID-19 disease

After TBI, increased glutamate release inhibits the normal function of System Xc-, thereby affecting GSH production and making it another ferroptosis pathway to consider in TBI (Guerriero et al., 2015)

Extracts can be sourced from different Pinus ( P .) species such as P