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We previously showed that oral intake of long-term oscillating glucose (LOsG, 4 times/day for 38 days) can lead to -cells gaining metabolic memory in reactive oxygen species (ROS) stress, inhibition of insulin and SOD-2 expression, and the development of prediabetes with hypoinsulinemia and glucose intolerance [3]
Similarly, it has been reported that Madin-Darby canine kidney cells infected with Sendai virus rapidly lost GSH, without increase in the oxidized products
While beneficial for normal growth, it poses a theoretical risk of accelerating the growth of existing or dormant cancers (for example, prostate, breast, colon) by inhibiting apoptosis (programmed cell death) and driving cell replication
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