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The core principle is chemical: copper is a redox-active metal, and pairing it carelessly with strong acids or potent oxidizers/reducers in the same layer can destabilize one or both ingredients and increase irritation
& Meeran, S
Yan S, Liu Q, Li W, Yan J, Fernie AR (2022) Raffinose family oligosaccharides: crucial regulators of plant development and stress responses
Some formulations combine copper peptides with vitamin C derivatives that are less prone to oxidation
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