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The higher sensitivity of MDA-T32 and MDA-T68 cells to RSL3 treatment may be due to the fact that RSL3 was originally selected from the chemical screen that showed synthetic lethality against RAS mutation and active TERT expressing cells 26
Science 310 , 683685 (2005)
Extended Half-Life Technology The LR3 modification involves 13 amino acid substitutions that reduce binding to IGF-binding proteins, allowing the peptide to remain active in the bloodstream for significantly longer periodstypically 20-30 hours compared to natural IGF-1s few hours
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