labial melanotic macule on lip Brown spots, especially the lips, can be alarming to some. In some instances it can indicate rare oral mucosal melanoma, however in this case it was a non-cancerous macule. Pigmented macular lip lesion -

Modifications of active site thiol groups by two redox-dependent aberrant post-translational modifications, S-glutathionylation and S-nitrosylation, lead to inactivation of the normal enzymatic activity of PDI (Walker et al., 2010)

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Orthopaedic Research Center, Colorado State University website Accessed July 31, 2015