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After the discoveries of the gastrointestinal hormones, secretin in 1902 and gastrin in 1905, there was a time when diabetes was treated by injecting intestinal extract, assuming that gastrointestinal hormones were involved in glycemic control of the pancreas [2]
doi: 10.1016/j.ejphar.2016.11.050 74
2 The medication is given as a once-a-week injection
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