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Although the ELIXA studythe only CVD outcome trial of GLP-1 RAs published to datereported a neutral cardiovascular effect of lixisenatide, the potential cardiovascular benefits of GLP-1 RAs should not be overlooked, because high-risk subjects with established CVD were recruited in this study to delineate its cardiovascular safety within a short-term period
There is no reported advantage to daily dosing over 23 weekly for fat loss specifically
Anagliptin, a DPP-4 inhibitor, suppresses proliferation of vascular smooth muscles and monocyte inflammatory reaction and attenuates atherosclerosis in male apo E-deficient mice
The one honest exception: TB-500 works partly by mass-action, so a higher local concentration in the brief window before it disperses is at least plausible
