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On the positive side, selective GLP-1 receptor agonism avoids the glucagon receptor-mediated hepatic glucose output and potential ketogenic effects that complicate dual agonist approaches
& Dunbrack, R
Clinicians may consider extending the time spent at lower doses if digestive side effects are problematic, as there is no requirement to rush escalation if patients are experiencing benefit and tolerating treatment reasonably well
At week 26, the reduction in waist circumferences were significantly greater with oral semaglutide than with empagliflozin [27]
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