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Willow also offers Odansetron to manage side effects if they occur
AMG 133 functionally inhibits GIP signalling through human and cynomolgus monkey GIPR with similar potency (half maximal inhibitory concentration (IC 50 ) of 42.4 nM and 26.5 nM, respectively), whereas it has more than 20-fold lower potency for inhibition of GIP signalling through rat GIPR (IC 50 = 822 nM) and did not fully antagonize mouse GIPR with concentrations of up to 3 M
Reports were more common in patients using GLP-1s for weight loss indications, which may reflect higher dosing, more rapid weight changes, or simply higher reporting rates in this population
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