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The underlying pathogenesis reflects a complex interplay between viral activity and the host immune response, driving progressive liver injury that can ultimately lead to serious complications such as cirrhosis and hepatocellular carcinoma (495)
The one human trial that will measure tolerability directly has not started reporting it is only recruiting (planned 2026), studies a topical gel on small standardized wounds , and lists safety as a secondary, not primary, outcome (NCT07437586)
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