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NNMT plays a key role in metabolic dysfunction, and its inhibition has been shown to reverse obesity-related changes in adipose tissue. Kraus et al., Cell Metabolism How 5-Amino-1MQ Works The primary mechanism behind 5-Amino-1MQ lies in its ability to inhibit nicotinamide N-methyltransferase (NNMT) an enzyme that is often overexpressed in fat cells, cancer cells, and aging tissues

High dose oral does not use the same mechanism as is generally used for B12 absorption

Vitamin B12 injections help combat these changes by supporting healthy red blood cell production and energy conversion at the cellular level

Potential Side Effects Reported side effects may include: Injection site pain, redness, or bruising Nausea or gastrointestinal discomfort Headache Dizziness Fishy body odor (associated with choline metabolism in some individuals) Allergic reaction seek immediate medical attention if you experience hives, swelling, difficulty breathing, or chest tightness Contact your prescribing provider promptly if you experience unexpected or concerning symptoms