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Comparing the metabolic phenotypes of conventionally-raised to germ-free mice under HFD, the intestinal microbiota promotes FXR-dependent weight gain and associated metabolic alterations such as hepatic steatosis and insulin resistance 42
Patients report smoother, more even-toned skin with improved elasticity
The gut plays a crucial role in maintaining energy and glucose homeostasis through extensive relays to the brain to inform the energy-regulating centers about incoming nutrient compositions
Similarly, the comparison of Wegovy and Zepbound places a spotlight on their use primarily for weight management, differing again in their composition and possibly side effect profiles
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