In people with normoglycemia and without excess adiposity, the incretin hormones GLP-1 and GIP work in concert to manage postprandial insulin levels, says Colleen Dawkins, FNP-C, RDN, CSOWM, a family nurse practitioner at Big Sky Medical Wellness, in Lakeside, Montana
Not sure which type it is
It cites SUSTAIN 6 for semaglutide and LEADER for liraglutide, both in type 2 diabetes, where it reports reduced cardiovascular events and mortality, plus SELECT for semaglutide in non-diabetic people with overweight
The combined activation of GIPR and GLP-1R by tirzepatide not only improved both glucose-dependent insulin secretion and glucose tolerance in mice 15 , but also showed significantly better efficacy than semaglutide and dulaglutide with regard to glucose control and weight loss 16,17