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Downstream effects commonly explored in experimental systems include modulation of IGF-1 signaling, protein synthesis pathways, lipid metabolism markers, and cellular repair processes
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Additionally, "some herbal or 'natural' remedies for constipation, like aloe, cascara, or senna-based products are stimulant-based," says Hamilton, "meaning they work by causing the intestines to contract more forcefully." While these supplements can be effective for short-term relief, Hamilton warns that frequent use can lead to cramping, diarrhea, or dependence
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