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Since the great majority of circulating IGF-I is normally sequestered in IGFBP complexes, an analogue that escapes that buffering behaves very differently in any system containing binding proteins, and that is the reason the IGF 1 LR3 variant exists as a reagent at all
[PMID: 16379035] Laboratory literature summary: Serum IGF-1 in studied acromegaly how normal is "normal"
Another shift that can be observed among incident patients is that of the age distribution: the proportion of the three younger age groups increased after 2021, while the two older age groups decreased
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