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Classic agonists like liraglutide, semaglutide, and dulaglutide mimic the natural signal but keep it on far longer
This poses a real challenge for Hims competition-wise
Taking compound 2 as an example, researchers optimized it and ultimately obtained the candidate drug PF-06882961, which has good agonistic activity on multiple signaling pathways
Some effects occur within minutes, such as blood glucose and insulin concentrations, while others, such as effects on synaptic density, muscle mass, or bone density, may take months
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