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Moreover, artificial tightening of MERCs in human fibroblasts leads to the induction of cellular senescence, a heightened proinflammatory secretory profile, and increased ROS production [106]

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AOD 9604 is a fragment of human growth hormone studied for its effect on fat metabolism, with a real but modest evidence base and an important regulatory caveat: it is not an FDA-approved weight loss drug

In MDA-MB-231 breast cancer cells, Lcn2 inhibition was shown to promote erastin-mediated ferroptosis, leading to reduced tumor cell proliferation, metastasis, and enhanced chemosensitivity to cisplatin ( in vitro and in vivo studies that chemotherapy resistance to gefitinib in TNBC is associated with GPX4-mediated oxidative stress