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Specifically, magnesium is required by several enzymes involved in the citric acid cycle and electron transport chain---mitochondrial processes that help turn the carbohydrates, proteins, and fats consumed in our diet into ATP

Maintain adequate hydration, as water-soluble vitamins like biotin require proper fluid balance for optimal function and excretion

Taking a moderate, highly bioavailable dose every day is generally more effective than taking a massive dose once a week

Mann DL, McMurray JJV, Packer M et al (2004) Targeted anticytokine therapy in patients with chronic heart failure: results of the randomized etanercept worldwide evaluation (RENEWAL)