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GIP appears to counteract some of the nausea-inducing effects of GLP-1
Further analysis of single-cell RNA sequencing data in fibroblasts, detailed in Figure S5 , provides a more comprehensive view of the transcriptional changes
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This ERMCS-localised GLP-1R signalling hub requires the engagement of the AKAP SPHKAP, known to assemble PKA-RI aggregates at the ER 32,33 , with VAPB playing a central role as the tethering factor responsible for the separate recruitments of GLP-1R and SPHKAP to ERMCSs, the latter via the direct interaction of VAPB with the pFFAT motif of SPHKAP
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