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The SUPRPASS-4 trial (262), involving 2002 participants with high-risk cardiovascular profiles followed for up to 104 weeks, showed no difference in 4-MACE events (cardiovascular death, myocardial infarction, stroke, and hospitalization for unstable angina) with tirzepatide compared to insulin glargine (HR 0.74
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In 2013 the two scientists reported that they had managed to create a drug candidate able to simultaneously target GLP-1 and GIP which they had found to effectively reverse obesity and insulin resistance in rodents, monkeys and humans
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