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Early data from the TRIUMPH trials is undeniably compelling, showing unprecedented weight loss of up to 28.7% at 68 weeks significantly outpacing tirzepatide in early comparisons (see our Retatrutide vs Tirzepatide comparison guide)
HDL cholesterol may initially decrease during active weight loss but generally increases with weight maintenance
Conditions such as hypothyroidism, polycystic ovary syndrome (PCOS), or severe insulin resistance can significantly slow progress
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