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3 Conclusion The troubling rise in the number of subjects affected by obesity worldwide has necessitated new scientific developments to blunt previous adverse effects of medication and facilitate administration, addressing different problems with a single drug
Cardiovascular Outcomes Analysis Major adverse cardiovascular events occurred less frequently than anticipated in both the retatrutide and placebo groups, resulting in relatively few events during the study
These findings lend support to the hypothesis that the increase in SHBG levels induced by liraglutide might contribute per se to reduce the risk of developing the metabolic syndrome in PCOS, also considering the effect of SHBG in directly suppressing inflammation and lipid accumulation in macrophages and adipocytes [65]
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