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Pending positive outcomes from ongoing and forthcoming RCTs, GLP-1 RA medications may become a pharmacotherapeutic approach for treating polysubstance use. Alcohol Addiction Among all substances, alcohol is by far the most investigated when it comes to GLP-1 RAs
Although the overall incidence is estimated at 1/5000 to 1/50,000, the occurrence of fatal hepatotoxicity could be as high as 1/800 to 1/500 in these high-risk groups [11]
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Factors to consider include: Weight Loss Goals: Tirzepatide may offer slightly more robust weight loss results, but semaglutide remains an excellent option for many patients
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