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Current clinical guidelines from major organizations including the American Diabetes Association (ADA) and the American Gastroenterological Association (AGA) do not specifically address combining tirzepatide with orlistat, reflecting the absence of robust clinical trial data for this combination

Supplementary material The Supplementary Material for this article can be found online at: References 1 AboubakrM.ElsaydF.SolimanA.FadlS

RT-qPCR analyses validated the upregulation of ATF4 target genes, including SLC1A1, SLC7A8 , phosphoserine aminotransferase 1 ( PSAT1 ), and serine hydroxymethyltransferase 2 ( SHMT2 ) in T315I-Bcr-Abl cells (Fig