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These metabolites are known to stimulate GLP-1 and PYY secretion and improve gut barrier function, processes that may enhance the metabolic efficacy of GLP-1 RA therapy when combined with dietary fiber enrichment ( The clinical relevance of such complementary approaches is highlighted by evidence showing that co-administration of probiotics, such as Limosilactobacillus fermentum GB102, with GLP-1RAs (e.g., dulaglutide) significantly enhances weight loss and attenuates weight regain after treatment cessation in obese mice ( While probiotics and prebiotics aim to reshape microbial communities and their metabolic activity, postbiotics offer an alternative strategy by directly delivering bioactive microbial products, particularly in individuals characterized by marked dysbiosis or reduced microbial diversity
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And even before retatrutide caught on, vendors linked to China were selling other peptidesa category of compounds that includes the obesity drugs semaglutide (Ozempic/Wegovy) and tirzepatide (Mounjaro/Zepbound), as well as substances, such as BPC-157, that are popular in fitness and wellness circles
