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Concomitant use results in cGMP accumulation and unpredictable falls in blood pressure and symptoms of hypotension [418-421]
Given the coupling between copper and energy status (e.g copper is a cofactor at Complex IV of the ETC) and how intensely metabolically active neurons are, it seems like short-term IP GHK-cu in the brain is acting analogously to the copper ionophore elesclomol in Tregs
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